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Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.
Shubina-Oleinik O, Nist-Lund C, French C, Rockowitz S, Shearer AE, Holt JR. Shubina-Oleinik O, et al. Sci Adv. 2021 Dec 17;7(51):eabi7629. doi: 10.1126/sciadv.abi7629. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910522 Free PMC article.
To develop gene therapy strategies for patients with STRC hearing loss, we generated a mouse model with a targeted deletion in the Strc gene. We devised a novel dual-vector approach to circumvent the size limitation of AAV vectors and drive expression of full …
To develop gene therapy strategies for patients with STRC hearing loss, we generated a mouse model with a targeted deletion in the Strc gene …
Novel DERMA Fusion Technique for ECG Heartbeat Classification.
Mastoi QU, Wah TY, Mohammed MA, Iqbal U, Kadry S, Majumdar A, Thinnukool O. Mastoi QU, et al. Life (Basel). 2022 Jun 6;12(6):842. doi: 10.3390/life12060842. Life (Basel). 2022. PMID: 35743873 Free PMC article.
The focus of this study is to classify five different types of heartbeats, including premature ventricular contraction (PVC), left bundle branch block (LBBB), right bundle branch block (RBBB), PACE, and atrial premature contraction (APC), to identify the exact condi …
The focus of this study is to classify five different types of heartbeats, including premature ventricular contraction (PVC), left bundle …
Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
Ohashi T, Kiehart DP, Erickson HP. Ohashi T, et al. J Cell Sci. 2002 Mar 15;115(Pt 6):1221-9. doi: 10.1242/jcs.115.6.1221. J Cell Sci. 2002. PMID: 11884521
We used FN-yellow fluorescent protein (FN-yfp) for the FN matrix, and the actin-binding domain of moesin fused to cyan fluorescent protein (cfp-Moe) to stain actin. Actin filament bundles were clearly seen in the protruding lamellae of the cells. FN matrix assembly appeare …
We used FN-yellow fluorescent protein (FN-yfp) for the FN matrix, and the actin-binding domain of moesin fused to cyan fluorescent protein ( …
Detection of Tick-Borne Bacteria from Whole Blood Using 16S Ribosomal RNA Gene PCR Followed by Next-Generation Sequencing.
Rodino KG, Wolf MJ, Sheldon S, Kingry LC, Petersen JM, Patel R, Pritt BS. Rodino KG, et al. J Clin Microbiol. 2021 Apr 20;59(5):e03129-20. doi: 10.1128/JCM.03129-20. Print 2021 Apr 20. J Clin Microbiol. 2021. PMID: 33627320 Free PMC article.
Pathogen-specific molecular methods have improved early diagnosis, but can be expensive when bundled together and may miss unexpected or novel pathogens. To address these shortcomings, we developed a 16S rRNA gene PCR with a next-generation sequencing (NGS) approach to det …
Pathogen-specific molecular methods have improved early diagnosis, but can be expensive when bundled together and may miss unexpected …
Automated detection of heart ailments from 12-lead ECG using complex wavelet sub-band bi-spectrum features.
Tripathy RK, Dandapat S. Tripathy RK, et al. Healthc Technol Lett. 2017 Feb 16;4(2):57-63. doi: 10.1049/htl.2016.0089. eCollection 2017 Apr. Healthc Technol Lett. 2017. PMID: 28894589 Free PMC article.
The complex wavelet sub-band bi-spectrum (CWSB) features are proposed for detection and classification of myocardial infarction (MI), heart muscle disease (HMD) and bundle branch block (BBB) from 12-lead ECG. The dual tree CW transform of 12-lead ECG produces CW coe …
The complex wavelet sub-band bi-spectrum (CWSB) features are proposed for detection and classification of myocardial infarction (MI), heart …
Estimation of diffusion properties in crossing fiber bundles.
Caan MW, Khedoe HG, Poot DH, den Dekker AJ, Olabarriaga SD, Grimbergen KA, van Vliet LJ, Vos FM. Caan MW, et al. IEEE Trans Med Imaging. 2010 Aug;29(8):1504-15. doi: 10.1109/TMI.2010.2049577. IEEE Trans Med Imaging. 2010. PMID: 20562045 Free article.
There is an ongoing debate on how to model diffusivity in fiber crossings. We propose an optimization framework for the selection of a dual tensor model and the set of diffusion weighting parameters b, such that both the diffusion shape and orientation parameters can be pr …
There is an ongoing debate on how to model diffusivity in fiber crossings. We propose an optimization framework for the selection of a du …
Dynamic Changes in Erectile Function and Histological Architecture After Intracorporal Injection of Human Placental Stem Cells in a Pelvic Neurovascular Injury Rat Model.
Gu X, Thakker PU, Matz EL, Terlecki RP, Marini FC, Allickson JG, Lue TF, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Gu X, et al. J Sex Med. 2020 Mar;17(3):400-411. doi: 10.1016/j.jsxm.2019.12.002. Epub 2020 Jan 27. J Sex Med. 2020. PMID: 32001204
AIM: To determine the effect of human placenta-derived stem cells on erectile function recovery and histological changes at various time points in a cavernous nerve injury rat model and to study the fate of injected stem cells throughout the regenerative process. METHODS: Human p …
AIM: To determine the effect of human placenta-derived stem cells on erectile function recovery and histological changes at various time poi …
Mechanistic insights into the benefits of multisite pacing in cardiac resynchronization therapy: The importance of electrical substrate and rate of left ventricular activation.
Sohal M, Shetty A, Niederer S, Lee A, Chen Z, Jackson T, Behar JM, Claridge S, Bostock J, Hyde E, Razavi R, Prinzen F, Rinaldi CA. Sohal M, et al. Heart Rhythm. 2015 Dec;12(12):2449-57. doi: 10.1016/j.hrthm.2015.07.012. Epub 2015 Jul 9. Heart Rhythm. 2015. PMID: 26165943
Invasive hemodynamic and electroanatomic assessment was performed during the following rhythms: baseline (non-CRT); biventricular (BIV) pacing delivered via the implanted CRT system (BIV(implanted)); BIV pacing delivered via an alternative temporary LV lead (BIV(alternative)); …
Invasive hemodynamic and electroanatomic assessment was performed during the following rhythms: baseline (non-CRT); biventricular (BIV) paci …